Phase 1 — Early testing in a small group of people (usually 20–80) to evaluate safety, determine safe dosage, and identify side effects.
(41 sites) United States
Orthopaedic Hemophilia Treatment Center, Los Angeles, California David Geffen School of Medicine at UCLA, Los Angeles, California Children's Hospital Los Angeles, Los Angeles, California University of California Davis, Sacramento, California University California San Francisco, San Francisco, California University of Colorado Hemophilia and Thrombosis Center, Aurora, Colorado Yale HTC, New Haven, Connecticut University of Florida, Gainesville, Florida Indiana Hemophilia and Thrombosis Center, Indianapolis, Indiana Tulane University School of Medicine, Louisiana Center for Bleeding and Clotting Disorders, New Orleans, Louisiana University of Michigan, Ann Arbor, Michigan Nationwide Children's Hospital, Columbus, Ohio Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania Australia
Royal Prince Alfred Hospital, Haemophilia Treatment Centre, Camperdown, New South Wales Canada
University of Alberta Hospital, Edmonton, Alberta McMaster University Medical Centre - Hamilton Health Sciences, Hamilton, Ontario McGill University Health Center (MUHC), Montreal, Quebec France
Hospices Civils de Lyon, Bron, Lyon Hemostase Clinique, Institut Coeur Poumon, Lille, Nord Hopital Necker, Paris, Île-de-France Region Germany
University Hospital Frankfurt, Frankfurt am Main, Hesse University Hospital Hamburg Eppendorf, Hamburg Italy
Careggi University Hospital, Florence, Firenze Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca Granda Ospedale Maggiore Policlinico, Milan, Lombardy Irccs Humanitas Research Hospital, Rozzano, Lombardy Ospedale san Bortolo, Vicenza Spain
Hospital Universitario Virgen del Rocio, Seville, Andalusia Complejo Hospitalario Universitario de A Coruña (Edificio Teresa Herrera-Materno Infantil), A Coruña, Galicia Hospital Clinico Universitario Virgen De La Arrixaca, El Palmar, Murcia Hospital Universitario Central de Asturias, Oviedo, Principality of Asturias Hospital Universitario Vall d'Hebron, Barcelona Hospital Universitario La Paz, Madrid Haemostasis and Thrombosis Unit, Hospital La Fe, Valencia Hospital Universitario Miguel Servet, Zaragoza United Kingdom
Glasgow Royal Infirmary - Clinical Research Facility, Glasgow, Scotland Queen Elizabeth Hospital Birmingham, Birmingham, West Midlands Addenbrooke's Hospital, Cambridge University Hospitals NHS FT, Cambridge Pathology and Pharmacy Building, The Royal London Hospital, London Royal Free London NHS Foundation Trust, London St. Thomas' Hospital, London Hammersmith Hospital Comprehensive Care Centre, London