Plain-English translation of NCT06383975 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial compares two different approaches to treat persistent atrial fibrillation (a type of irregular heartbeat) in people whose first ablation procedure did not work. One approach uses pulsed field energy to isolate the back wall of the heart; the other combines radiofrequency ablation with ethanol infusion in a vein called the vein of Marshall. Both treatments aim to stop the irregular heartbeat from coming back.
After the first ablation procedure, 20–50% of people with persistent irregular heartbeat experience a recurrence. When this happens, doctors need a clear strategy for the second procedure, but there is no consensus on the best approach. This trial tests two promising strategies to determine which works better for people whose heartbeat remains irregular despite their first treatment.
You likely qualify if…
You likely don't qualify if…
You will be randomly assigned to receive one of two catheter ablation procedures as a redo treatment. The procedure itself is performed in a hospital setting by specialists, similar to your first ablation but with the additional treatment approach your group receives. You will likely have follow-up visits to monitor your heart rhythm and check for symptom improvement.
AI-generated summary from trial data · Jun 28, 2026 · Not medical advice
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