Plain-English translation of NCT06387446 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is studying allogeneic valve transplantation — a procedure where a donated heart valve is transplanted into children and young adults who need valve replacement. The goal is to use a valve that can grow with the patient over time, potentially reducing the need for multiple surgeries throughout life.
Many children with heart valve disease currently have limited options for valve replacement, and most replacement valves do not grow as the child grows, requiring additional surgeries as they get older. This trial explores whether transplanted valves can provide a longer-lasting solution that adapts to the patient's growth.
You likely qualify if…
You likely don't qualify if…
If you qualify, you will receive the transplanted valve through heart surgery at Boston Children's Hospital. After the procedure, you will need to attend regular follow-up appointments at the hospital to monitor how well the valve is working and how it grows with you over time. The trial will track your outcomes and any side effects for 5 years, requiring you to share medical records and attend periodic check-ins.
AI-generated summary from trial data · Aug 24, 2026 · Not medical advice
United States
Sponsor
Boston Children's Hospital
Enrollment target
~4 participants
Started
May 2024
Primary completion
June 2027
Age range
30 Days – 50 Years
Last updated on clinicaltrials.gov in September 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Sitaram Emani, MD
Boston Children's Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.