Plain-English translation of NCT06387914 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
The EPIONE trial is testing deep brain stimulation (DBS), a treatment where a small device is surgically implanted to deliver electrical pulses to specific areas of the brain. Researchers want to see if this treatment can reduce chronic pain in people who have central post-stroke pain that hasn't improved with standard medications or therapies. You would receive the device and then try two different stimulation settings to see which works better for your pain.
Most previous research on brain stimulation for chronic pain consists of small case studies rather than rigorous controlled trials, making it hard to know how well this treatment truly works. This trial uses modern scientific methods to give us a clearer answer about whether this treatment can help people with long-lasting post-stroke pain.
You likely qualify if…
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You would undergo brain surgery to have the stimulation device implanted. After that, you would participate in two 1-month periods where the device is turned on with different settings—one optimized for pain relief and one with low stimulation (which acts as a control). You would not know which setting is active each month. Following these two months, you would enter a 6-month period where your doctors fine-tune the settings based on your individual needs and symptoms, potentially using features like adjusting stimulation during sleep or movement.
AI-generated summary from trial data · Jul 7, 2026 · Not medical advice
United Kingdom