Plain-English translation of NCT06390423 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Patients with severe lung failure who are on breathing machines often need extra fluids, but doctors aren't always sure how much fluid is safe or helpful. This study compares several different bedside tests—including heart ultrasounds, breathing measurements, and brief physical maneuvers—to see which methods best predict whether a patient will actually improve with extra fluids.
Giving too much fluid to patients with severe lung failure can cause serious harm, but not giving enough can also be dangerous. Right now, doctors use different methods to decide if a patient needs more fluid, and no single method is perfect. This trial will help doctors figure out which combination of tests works best to make the right choice.
You likely qualify if…
You likely don't qualify if…
You will have several bedside tests performed while you are sedated and on a breathing machine. These include a heart ultrasound, measurements from monitors already attached to you, and a brief test where your legs are raised passively. If the initial tests suggest you might benefit from fluids, you'll receive a small amount of extra fluid (250 milliliters) over 10 minutes, and then the measurements will be repeated to see how your heart responds.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
United States
Sponsor
CentraCare
Enrollment target
~64 participants
Started
July 2023
Primary completion
June 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
30 Years – 90 Years
Last updated on clinicaltrials.gov in August 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Ramakanth Pata
Centracare health System
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.