Receive magnetic brain stimulation at different strength levels to test depression treatment

Receive magnetic brain stimulation at different strength levels to test depression treatment | stella

What is this trial?

This trial is testing intermittent theta-burst stimulation (iTBS), a type of magnetic brain stimulation that has been approved by the FDA to treat major depression. Researchers want to figure out the best strength level to use—whether the standard high-intensity treatment is actually better than a lower, more comfortable intensity. Your participation would help doctors understand which strength works best and causes the least discomfort.

Currently, doctors use this treatment at a high intensity level (120% of a standard measurement), which can be quite uncomfortable for patients. However, research suggests that lower intensities might work just as well or even better, and scientists don't yet have clear evidence about which strength is truly most effective for treating depression.

Do you qualify?

You likely qualify if…

you are between 18 and 70 years old
you have been diagnosed with major depressive disorder and have tried at least two different antidepressant medications without success
you have a depression severity score of at least 18 on a standard rating scale
you have been on a stable dose of psychiatric medication for at least 4 weeks before enrolling
your recent blood work shows normal thyroid function, blood counts, and liver function

You likely don't qualify if…

you have used drugs or alcohol heavily in the past 3 months
you have a cardiac pacemaker, metal implants, or other devices that would conflict with magnetic stimulation
you have active thoughts of suicide or self-harm
you are pregnant or planning to become pregnant
you have a history of bipolar disorder, schizophrenia, or any psychotic disorder

What participation looks like

You would be randomly assigned to receive magnetic brain stimulation at one of three different intensities: a sham (inactive) treatment, a lower intensity (75%), or the standard high intensity (120%). The stimulation sessions would take place at a hospital or clinic, and you would need to attend multiple treatment visits over several weeks. Researchers would monitor your depression symptoms and how you respond to the treatment throughout the study.

AI-generated summary from trial data · Jul 8, 2026 · Not medical advice

Finding the Right Strength for Brain Stimulation in Depression

What is this trial?

Do you qualify?

What participation looks like

Trial locations(1 site)