Can a urine test reduce unnecessary bladder camera procedures for microscopic blood in urine?

Plain-English translation of NCT06394869 on ClinicalTrials.gov ↗ · Source last updated July 2026 · Translation generated July 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing whether a urine test called Cxbladder Triage Plus can help reduce the number of unnecessary bladder camera procedures (cystoscopies) in people who have microscopic blood in their urine. The test checks for genetic changes in urine that may indicate bladder cancer risk. By using this information, doctors and patients can make a shared decision about whether a bladder camera procedure is truly needed.

Microscopic blood in urine can be caused by many things, and while bladder cancer is a concern, it's actually found in only a small number of patients. Currently, most patients get a bladder camera procedure to rule out cancer, even though many don't need it. This trial wants to see if the new test can help avoid unnecessary procedures while still catching the cases that matter.

Do you qualify?

You likely qualify if…

you have microscopic blood in your urine detected on a recent test
you are between 19 and 88 years old
you are able to provide a urine sample and have a bladder that has not been surgically altered
you speak English (or Spanish with an interpreter) well enough to understand and follow study instructions
you are able and willing to give written consent and follow all study requirements

You likely don't qualify if…

you have a history of bladder cancer or other cancers of the urinary tract
you have had severe bleeding in your urine requiring hospitalization or procedures in the last 12 months
you have had pelvic radiation or are currently receiving chemotherapy
you have a surgically reconstructed or diverted bladder
you are currently pregnant

What participation looks like

You will provide a urine sample for the genetic test. You will then be randomly assigned to one of two groups: either your doctor will receive the test results and discuss them with you to decide together whether you need a bladder camera procedure, or your doctor will make the decision using standard practice without the test results. The study follows your care and tracks whether you have a bladder camera procedure and what happens afterward.

AI-generated summary from trial data · Jul 4, 2026 · Not medical advice

Trial locations(20 sites)

United States

Urology Centers of Alabama, Homewood, Alabama

Urology Associates of Mobile, Mobile, Alabama

Urology Associates of Central California, Fresno, California

Urology Group of Southern California, Los Angeles, California

Comprehensive Urology, Los Angeles, California

View full record on ClinicalTrials.gov