Plain-English translation of NCT06396260 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This research study uses two types of advanced brain imaging — one that looks at brain tissue structure and another that measures brain activity — to better understand how ALS affects the brain. The study is especially interested in pseudobulbar affect, which is a condition where people with ALS experience sudden, involuntary episodes of laughing or crying that don't match what they're feeling. By comparing brain scans from people with ALS (with and without this symptom) and healthy volunteers, researchers hope to discover what's happening in the brain that causes these emotional changes.
Many people with ALS experience pseudobulbar affect, but we don't fully understand why it happens or how it relates to changes in the brain. This study aims to fill that gap by looking directly at brain structure and activity, which could eventually lead to better treatments and support for people dealing with this challenging symptom.
You likely qualify if…
You likely don't qualify if…
If you join this study, you would have brain imaging scans performed — including a special MRI scan and a magnetoencephalography (MEG) scan that measures brain activity. Healthy volunteers would come in once for these baseline scans. People with ALS would be scanned at the beginning and then again 6 months later to see if anything changes over time. The visits are designed to work with your abilities, whether you need adaptive technology or other support to participate.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
Denmark
Sponsor
Aalborg University Hospital
Collaborators
University of Aarhus
Enrollment target
~50 participants
Started
May 2024
Primary completion
October 2026
Age range
18 Years – 90 Years
Last updated on clinicaltrials.gov in January 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Christian Holm Steenkjær
Aalborg University Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.