Plain-English translation of NCT06397235 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a combination of two catheter-based treatments — (a procedure that delivers chemotherapy beads directly to the tumor's blood supply) plus RALOX-based HAIC (an additional chemotherapy infusion through the same catheter) — works better than alone for treating large liver cancers that cannot be surgically removed. Half the participants will receive the combination treatment, and half will receive alone, to see which approach helps patients live longer and controls their cancer better.
Large liver cancers that cannot be surgically removed are very difficult to treat. Current treatments like help some patients, but doctors are exploring whether adding a second chemotherapy infusion through the same catheter can improve results and give patients better chances of survival or even make their tumors small enough for surgery.
You likely qualify if…
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You will be randomly assigned to receive either the combination treatment ( plus RALOX-HAIC) or alone. Both involve catheter procedures performed by specialists, usually repeated every 4 weeks as needed based on imaging and blood tests. Between treatments, you will have regular follow-up visits with blood work and imaging scans to monitor how your tumor is responding. If your cancer shrinks enough to become operable during the trial, your medical team will discuss surgery as an option.
AI-generated summary from trial data · Jun 4, 2026 · Not medical advice
China
Phase
Testing effectiveness
Sponsor
Second Affiliated Hospital of Guangzhou Medical University
Collaborators
Zhongshan People's Hospital, Guangdong, China, Guangzhou Development District Hospital
Enrollment target
~130 participants
Started
May 2024
Primary completion
April 2027
Age range
18 Years – 75 Years
Last updated on clinicaltrials.gov in February 2025.
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