Plain-English translation of NCT06398938 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This trial is testing an accelerated form of internal radiation therapy (called brachytherapy) combined with chemotherapy for people with locally advanced cervical cancer. Researchers want to understand how well this faster treatment works and how it affects side effects, particularly damage to the bowel and bladder, as well as sexual function.
Standard cervical cancer treatment can take several weeks and sometimes causes lasting damage to nearby organs. This trial explores whether delivering the radiation faster and more precisely might improve outcomes while reducing these serious side effects.
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You would receive standard chemotherapy followed by accelerated internal radiation therapy (brachytherapy) delivered over a shorter timeframe than usual. The study will track you over time to measure any side effects on your bowel, bladder, and sexual function. Researchers will use MRI imaging to guide the radiation precisely to the tumor while protecting healthy tissues nearby.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
Italy
Sponsor
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Enrollment target
~129 participants
Started
May 2024
Primary completion
May 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years and older
Sex
Female only
Last updated on clinicaltrials.gov in August 2025.
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Central contact
VALENTINA LANCELLOTTA
Fondazione Universiataria Policlinico A Gemelli IRCCS
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