Plain-English translation of NCT06399731 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Parkinson Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing two non-invasive brain stimulation techniques — repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) — to see if they can help improve thinking and memory problems in people with Parkinson's disease. About 40% of people with Parkinson's experience mild cognitive impairment (difficulty concentrating, mental flexibility, or processing speed), and currently there is no proven treatment for this. Researchers want to find out if these brain stimulation methods are acceptable and feasible for patients to use.
Mild cognitive impairment is common in Parkinson's disease and can affect daily life and quality of life, but current medications and therapies haven't been very effective. Brain stimulation offers a promising new approach, but researchers need to understand whether it's practical and tolerable for people with Parkinson's who may have motor and cognitive challenges.
You would be randomly assigned to receive either rTMS first or tDCS first. The trial lasts about 16 weeks total and involves four phases, each lasting 4 weeks: a baseline period with no treatment, a 4-week stimulation period (either rTMS or tDCS), another baseline period, and then the second stimulation method. rTMS requires you to visit the hospital three times a week for 20-minute sessions, while tDCS can be done at home five times a week for 20 minutes. You'll also complete thinking and memory tests and brain imaging at different points throughout the study.
AI-generated summary from trial data · Jun 10, 2026 · Not medical advice
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