Testing a seizure prevention medication after cardiac arrest

After cardiac arrest, many survivors develop dangerous seizures that are hard to treat and can cause serious harm. This trial is testing whether a medication called perampanel, already used to treat certain seizures, might prevent these dangerous seizures from starting in the first place. The study will compare the medication to a placebo to see if it is safe and whether it actually works.

Seizures happen in about one-third of people who survive cardiac arrest, and these seizures are very difficult to control with current treatments. Most patients with these severe post-arrest seizures do not survive. This medication has been used to manage severe seizures, but doctors want to test whether giving it early—before seizures start—might save more lives.