Plain-English translation of NCT06403839 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This research is investigating whether dental screening before heart valve replacement surgery can help prevent a serious heart infection called infective endocarditis. Currently, doctors recommend checking patients' teeth and treating any problems before valve surgery, but no one knows for certain if this actually reduces infection risk. This study will compare patients who received dental screening before surgery with those who did not, to see if it makes a real difference.
Patients who receive artificial heart valves face a higher-than-normal risk of developing a serious infection in the heart. Medical organizations recommend dental screening before surgery, but this recommendation is based on limited evidence rather than rigorous studies, so researchers want to confirm whether this screening actually protects patients.
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You would be part of a registry where your medical information and dental records before surgery are collected and tracked. Researchers will follow your health outcomes after your valve surgery to compare infection rates between patients who received dental screening and those who did not. This is an observational study, meaning you are not randomly assigned to a treatment group—the researchers simply observe and record standard clinical practice at participating hospitals.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
Denmark
Enrollment target
~1,000 participants
Started
January 2020
Primary completion
March 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in August 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Lytfi Krasniqi, MD
Denmark Odense University Hospital
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.