Plain-English translation of NCT06406530 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing PRF — a substance made from your own blood — to see if it helps tooth extraction sockets heal better before you receive radiation therapy for head and neck cancer. Researchers want to compare healing when PRF is applied to one extraction site versus letting another site heal naturally, to understand if this simple treatment can prevent serious bone complications that sometimes occur after radiation.
Patients with head and neck cancer often need teeth removed before radiation therapy to prevent infections and bone damage. Recent studies suggest that PRF may speed up healing and reduce pain after tooth extraction, but doctors don't yet know if this treatment can actually prevent the severe bone problems that radiation can cause.
You likely qualify if…
You likely don't qualify if…
You will have at least two teeth extracted before your radiation therapy begins. During the surgery, one extraction site will randomly receive PRF treatment while the other heals naturally — neither you nor your doctor will know which side received the treatment. Over the next 7 days, you'll track your pain and painkiller use at home. You'll return for follow-up visits at 2 weeks, 3 weeks, and 1 month to check healing, then again at 3 months and 6 months to monitor for any complications from radiation and to take X-rays comparing both sides.
AI-generated summary from trial data · Jul 18, 2026 · Not medical advice
Germany
Sponsor
University of Giessen
Enrollment target
~34 participants
Started
December 2023
Primary completion
August 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
18 Years – 99 Years
Last updated on clinicaltrials.gov in April 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Sameh Attia, DDS, MSc
UKGM
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.