Plain-English translation of NCT06407518 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether midazolam, a medication that promotes sleep and reduces anxiety, can help reduce pain after laparoscopic colorectal cancer surgery. The study focuses on patients who have trouble sleeping or feel anxious before surgery. Researchers believe that treating these sleep and anxiety problems before surgery may lead to less pain and better recovery afterward.
Many colorectal cancer patients experience sleep problems and anxiety before surgery, and research shows this can make postoperative pain worse and harder to manage. There is no clear medical guidance on the best way to treat these issues before surgery, so this trial aims to see if this medication can effectively help.
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If you qualify, you will be randomly assigned to receive either the active medication or a placebo (an identical-looking but inactive treatment) to take by mouth each night starting when you are admitted to the hospital until the night before your surgery. The study staff will monitor your response—if you don't fall asleep within 30 minutes, your dose may be increased slightly. After surgery, researchers will track your pain levels and recovery to see if the medication helped reduce postoperative discomfort.
AI-generated summary from trial data · Jun 18, 2026 · Not medical advice
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