Plain-English translation of NCT06408246 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Depression research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a medication called , when added to (a common antidepressant), can help people with depression who struggle with concentration and decision-making. Researchers believe that some people with depression have specific cognitive problems that may respond better to this combination of treatments. The study will compare how well the medication works compared to alone over 8 weeks.
Standard antidepressants help mood, but some people with depression still struggle with thinking problems like focus and planning. This trial is testing whether adding this medication could address both mood and thinking difficulties at the same time.
You likely qualify if…
You likely don't qualify if…
If you qualify, you'll have an initial screening visit with cognitive tests and questions about your mood, followed by an in-person medical screening (blood work, vitals, urine sample). Then you'll have a brain scan, after which you'll be randomly assigned to receive either the medication combination or with a placebo. For 8 weeks, you'll take your assigned medication daily, complete nightly surveys on your phone, attend weekly virtual appointments with a doctor, and do brief cognitive testing each week.
AI-generated summary from trial data · Jul 5, 2026 · Not medical advice
United States