Plain-English translation of NCT06409832 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Migraine research guide →This study is testing a medication called rimegepant as a preventive treatment for migraine in everyday clinical settings across multiple hospitals and clinics. Rimegepant is a newer type of medication that works by blocking a protein involved in migraine, and early research has shown it can reduce how often migraines occur. This study aims to see how well the medication works and how patients tolerate it when used regularly over a longer period in real-world conditions.
While earlier research has shown promise for this medication in preventing migraines, doctors and researchers want to better understand how well it works and how patients tolerate it when they use it regularly in everyday practice rather than in controlled research settings.
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You would take the medication by mouth every other day for up to two years. You'll visit the clinic at the start and then every three months to answer questions and provide updates. You'll keep a simple headache diary each month to track how many migraine days you have, how severe they are, and any side effects you experience. The study team will use this information to understand how well the medication works for preventing migraines and how well you tolerate it over time.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
Italy
Sponsor
University of Florence
Collaborators
IRCCS National Neurological Institute "C. Mondino" Foundation, Società Italiana per lo Studio delle Cefalee
Enrollment target
~100 participants
Started
March 2024
Primary completion
January 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in January 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Luigi F Iannone, MD
University of Florence
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.