Plain-English translation of NCT06410599 on ClinicalTrials.gov ↗ ·
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether hydrochloride, when combined with standard therapy, can help people with chronic depression that hasn't improved despite trying multiple antidepressants and therapy. The study also tests a specialized therapy called CBASP, either alone or combined with the medication. Researchers want to see if these combinations work better than standard treatment alone.
Many people with long-lasting depression don't improve even after trying multiple antidepressants and undergoing therapy. This trial exists to find new treatment options for people whose depression has been resistant to standard approaches.
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You will attend a screening visit lasting about 100 minutes, including interviews, blood work, and a heart activity test. If accepted, you will be randomly assigned to one of three groups: standard therapy plus medication, standard therapy plus specialized therapy, or standard therapy plus placebo. You will then receive two therapy sessions per week for 12 weeks, with the medication or placebo given during weeks 4–6. Throughout the study, you'll be monitored to see how your depression symptoms improve.
AI-generated summary from trial data · Jul 11, 2026 · Not medical advice
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