Recruiting

Testing a laser device to repair aortic aneurysms near kidney arteries

Plain-English translation of NCT06411990 on ClinicalTrials.gov ↗ · Source last updated September 2026 · Translation generated October 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing the LIFE device, a specialized stent graft system that uses laser technology to treat aortic aneurysms in a specific location near your kidney arteries. Instead of open surgery, the device is inserted through blood vessels in your groin and guided into place inside your aorta. This treatment is designed for patients who cannot safely have standard endovascular devices or open surgery.

Many patients with complex aortic aneurysms near the kidney arteries don't have safe treatment options available—they may be too weak for open surgery, live far from specialized centers, or have anatomy that doesn't fit standard devices. This trial exists to provide a potentially life-saving alternative for these patients.

Do you qualify?

You likely qualify if…

you have an aortic aneurysm larger than 5.5 cm (if male) or 5.0 cm (if female), or your aneurysm is growing rapidly and at risk of rupture
your aneurysm is located in the juxtarenal or pararenal aorta (near your kidney arteries)
you are not a good candidate for open surgery due to conditions like kidney disease, obesity, heart disease, lung disease, or diabetes
you are not able or willing to travel to centers with manufacturer-made investigational devices
you are 18 years or older and able to attend follow-up visits

You likely don't qualify if…

you have allergies or sensitivities to materials like nitinol, polyester, platinum, stainless steel, or heparin
you cannot safely take blood thinners or receive contrast dye, or your blood clotting cannot be corrected
you are currently enrolled in another experimental therapy research study
your body size or anatomy would make it unsafe to visualize or treat your aorta with this device

What participation looks like

You would undergo a minimally invasive endovascular procedure where the LIFE device is inserted through blood vessels in your groin and positioned inside your aorta using a laser catheter passed through an artery in your arm. The procedure uses imaging guidance to ensure the graft covers the aneurysm while preserving blood flow to your kidney and other vital organs. You would then participate in follow-up clinic visits and imaging studies to monitor how well the graft is working.

AI-generated summary from trial data · Oct 6, 2026 · Not medical advice

Trial locations(1 site)

United States

University of Missouri - Columbia, Columbia, Missouri