Plain-English translation of NCT06413368 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing a medication called maralixibat to see if it can help relieve constipation in children with cystic fibrosis. Constipation is common in CF because the condition affects how the intestines handle water and salt, leading to hard stools and discomfort. The medication works in a different way than standard laxatives, and researchers want to see if adding it to your child's current constipation treatments makes stools easier to pass.
Many children with cystic fibrosis continue to have hard, uncomfortable stools even when taking regular laxatives. Doctors need to find new treatment options that work differently to help these children feel better.
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Your family will first observe your child's bowel habits for a baseline period while continuing current medications. Then your child will take the new medication for two weeks in addition to their usual constipation treatments. Throughout the study, you'll track and record stool characteristics and bathroom symptoms using simple tools provided by the research team. The study design allows researchers to compare how your child does before and after starting the medication.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
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