Plain-English translation of NCT06414356 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.
This trial is testing whether infusions—given through an IV—can help reduce chronic nerve pain and symptoms of post-traumatic stress in military service members and veterans. Some participants will receive alone, others will receive combined with magnesium, and some will receive magnesium only as a comparison. Researchers want to understand whether this medication can safely improve pain and quality of life for people whose nerve pain hasn't improved with other treatments.
Chronic nerve pain and trauma-related stress disorders are common in military populations and are often difficult to treat with standard pain medications. Early research suggests that this medication may help both conditions, but researchers need to study it more carefully to confirm whether it works and whether adding magnesium makes it more effective.
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You would visit a clinic multiple times over 6 weeks to receive infusions through an IV. Weeks 1–2 involve three visits per week, weeks 3–4 involve two visits per week, and weeks 5–6 involve one visit per week. Each infusion takes about 4 hours, and you must stay in the clinic for at least an hour afterward and arrange for someone to pick you up. You'll also complete questionnaires before and after each visit about your pain, mood, and quality of life. You'll return for check-in visits at 10 weeks and 24 weeks after your final treatment. Throughout the study, you can continue taking your regular pain medications as needed.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
United States