Saving the bladder with chemotherapy and radiation for aggressive bladder cancer

This trial is testing whether a combination treatment called trimodal therapy can work for people with an aggressive form of bladder cancer that has unusual cell types mixed in with standard cancer cells. Trimodal therapy combines three approaches: a procedure to remove the tumor, chemotherapy, and radiation therapy — all working together to try to save your bladder instead of requiring surgical removal.

Most aggressive bladder cancers are treated by surgically removing the entire bladder, which dramatically changes a patient's quality of life. This trial exists because there is very limited research on whether the new treatment approach can work effectively for people whose bladder cancer has these unusual cell patterns, even though it has shown promise in patients with standard bladder cancer.