Plain-English translation of NCT06418113 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Glioblastoma research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing a new treatment order for glioblastoma, an aggressive brain cancer. Instead of removing the tumor first, this study gives patients radiation therapy and before surgery to see if that approach is safe and may work better. The medication used is temozolomide.
The standard treatment for glioblastoma hasn't changed much in nearly 20 years. Researchers want to know if giving radiation and the medication before surgery—rather than after—might help patients live longer and feel better while keeping side effects manageable.
You likely qualify if…
You likely don't qualify if…
You would first have a small biopsy to confirm the exact type of brain tumor. If you qualify, you would receive 15 sessions of radiation therapy over 3 weeks while taking medication daily. Five weeks later, you would have brain surgery to remove the tumor, guided by special imaging to protect healthy brain tissue. After surgery, you would take the medication for 6 months. Throughout, you would have regular doctor visits, scans, and tests to check how you're doing, with follow-up visits continuing for 2 years.
AI-generated summary from trial data · Aug 5, 2026 · Not medical advice
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