Plain-English translation of NCT06420492 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ulcerative Colitis research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing a medication called to see if it can help people with severe ulcerative colitis—particularly those whose symptoms aren't controlled by standard treatments. Participants will take the medication by mouth for 4 weeks, and researchers will carefully track how well it works and whether it's safe. The study involves about 20 people and will last 12 weeks total.
Many people with severe ulcerative colitis don't get better with current treatments, leaving them with painful symptoms and ongoing inflammation. This trial exists to see whether this new treatment option could help patients who have run out of other choices.
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You will take the study medication by mouth twice daily for 4 weeks, possibly with an initial IV dose. You'll attend 8 visits to the study site over 12 weeks, where you'll have blood drawn, provide stool and urine samples, and possibly undergo a scope procedure to look inside your colon at the start and end of the study. You'll keep a log of your medication and track how you're doing.
AI-generated summary from trial data · Jun 11, 2026 · Not medical advice
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