Plain-English translation of NCT06421818 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ulcerative Colitis research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether Baitouweng Decoction, a traditional herbal medicine, can help treat ulcerative colitis when delivered directly into the colon using a special tube. The study will compare this direct delivery method to two other ways of giving the medication—by rectal enema and by mouth—to see which works best. Researchers will also study how the medication affects your gut bacteria and immune system.
Ulcerative colitis is a chronic condition that causes inflammation and bleeding in the large intestine, and many patients struggle with current treatments. This trial is exploring whether delivering the medication directly to the affected area of the colon using a special tube might be more effective than traditional methods, while also studying the medication's effects on gut health.
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If you enroll, you will be randomly assigned to one of four groups: receiving the herbal medication through a tube placed in your colon, receiving a placebo (inactive treatment) through the same tube, receiving the medication by rectal enema, or taking the medication by mouth. The treatment lasts 10 days, and you will have samples collected from your stool, blood, and urine before and after treatment to study changes in your gut bacteria, immune system, and overall health. You should expect colonoscopy procedures and regular follow-up appointments to monitor your progress.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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