Plain-English translation of NCT06424015 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how insulin — a hormone that controls blood sugar — affects glucagon, another hormone that raises blood sugar. This is especially important in people with prediabetes, where the body is losing its ability to control blood sugar properly. The study will use safe IV infusions to mimic insulin resistance and measure how hormones respond.
In prediabetes, the body's cells don't respond well to insulin, and the hormones that control blood sugar get out of balance. This research will help scientists understand exactly how insulin normally keeps glucagon in check, so they can develop better treatments to prevent or slow the progress from prediabetes to type 2 diabetes.
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You will visit the research center for a long study day (from early morning to early afternoon). During this time, researchers will place an IV line and infuse either a special fat emulsion (to temporarily create insulin resistance) or saline (salt water) into your bloodstream. Blood samples will be taken at regular intervals to measure your insulin, glucagon, and glucose levels. The entire visit will last several hours, and you'll need to fast beforehand.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
United States
Enrollment target
~60 participants
Started
September 2024
Primary completion
September 2026
Age range
25 Years – 65 Years
Last updated on clinicaltrials.gov in October 2025.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Kim Osmundson, CCRP
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.