Plain-English translation of NCT06424106 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
Researchers want to understand how two hormones—glucagon and glucose—work together to control fasting blood sugar levels. This study will give you infusions of glucagon on one day and glucose on another day, while measuring how your body responds. The goal is to understand why some people develop high fasting blood sugar even before they have diabetes.
Fasting blood sugar (the level when you haven't eaten overnight) plays a big role in early diabetes and related complications, but doctors don't fully understand how it gets out of balance. This research aims to fill that gap by studying how hormones communicate in people at risk for diabetes.
You likely qualify if…
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You will visit Mayo Clinic on two separate days. On one day, researchers will give you a glucagon infusion through an IV that gradually increases over 4 hours. On another day, you'll receive a glucose infusion adjusted to match your blood sugar from the first day. Throughout both visits, they'll take blood samples to measure how your body's hormones and blood sugar respond.
AI-generated summary from trial data · Jun 1, 2026 · Not medical advice
United States
Mayo Clinic
Enrollment target
~60 participants
Started
April 2025
Primary completion
July 2027
Age range
25 Years – 65 Years
Last updated on clinicaltrials.gov in April 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Kim Osmundson, CCRP
Mayo Clinic
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.