Plain-English translation of NCT06425224 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing a treatment called transcutaneous posterior tibial nerve stimulation — a non-invasive therapy where small electrodes placed on your leg deliver mild electrical stimulation. Researchers want to see if this nerve stimulation can help men with premature ejaculation, and whether combining it with the medication dapoxetine works better than either treatment alone.
Premature ejaculation affects many men and can cause stress and frustration. While medications like dapoxetine exist, not all men respond well to them or prefer to take pills. This trial explores whether stimulating a specific nerve in the leg might offer an alternative or better solution.
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If you're selected, you'll be randomly assigned to one of three groups: nerve stimulation with placebo pills, medication alone, or nerve stimulation plus the medication. Those receiving nerve stimulation will visit the clinic 3 times per week for 12 weeks, with each 30-minute session involving electrodes placed on your leg. You may also take pills (either active medication or placebo) a few hours before sexual activity. The study lasts about 3 months, and researchers will measure how well the treatment works and check for any side effects.
AI-generated summary from trial data · Aug 25, 2026 · Not medical advice
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