Plain-English translation of NCT06428396 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether , a new medication, works better when combined with an existing hormone therapy called compared to another standard treatment ( plus hormone therapy). The study is for people with a specific type of advanced breast cancer (estrogen receptor positive, HER2 negative) whose cancer has continued to grow despite previous hormone treatments.
Many people with this type of advanced breast cancer eventually stop responding to standard hormone treatments, and researchers are looking for new combinations that might help the cancer shrink or stop growing.
If you qualify, you will be randomly assigned to receive either the new medication () by mouth once daily plus injections, or a standard treatment ( by mouth plus hormone therapy). You will take or receive these treatments in 28-day cycles until your cancer progresses or you decide to stop. You'll have regular visits to check how well the treatment is working and monitor for side effects.
AI-generated summary from trial data · Jul 15, 2026 · Not medical advice
United States