Plain-English translation of NCT06428396 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This study is testing , a new medication, paired with (a hormone therapy injection) to see if this combination can slow down or stop advanced breast cancer that no longer responds to previous hormone treatments. You would be randomly assigned to receive either this new combination or the current standard treatment ( plus hormone therapy). The goal is to find out which approach works better and is safer for people in your situation.
Many people with advanced breast cancer eventually stop responding to standard hormone treatments, and doctors need better options to help them. This trial is testing whether this medication could be a more effective choice for patients whose cancer has progressed despite previous therapy.
You likely qualify if…
You likely don't qualify if…
If you enroll, you'll be randomly assigned to one of two treatment groups. One group takes a daily pill () and receives injections of , while the other group takes a daily pill () and either injections or another daily pill for hormone therapy. You'll continue treatment in 28-day cycles until your cancer progresses or you experience side effects that require stopping. You'll have regular visits to your doctor to monitor how the treatment is working and check for any side effects.
AI-generated summary from trial data · Jun 9, 2026 · Not medical advice
United States