Plain-English translation of NCT06438588 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a fasting-mimicking diet (FMD) can help reduce unwanted side effects from immunotherapy — a type of cancer treatment that trains your immune system to fight tumor cells. You would follow this special diet for 4 days during three cycles of your immunotherapy treatment, with support from a nutritionist. The study aims to understand if this dietary approach can lower the rate and severity of immune-related side effects while keeping your quality of life as good as possible.
Immunotherapy is very effective for many advanced cancers, but it can trigger side effects when the immune system becomes overactive and attacks healthy organs — particularly the digestive system. This trial exists to see whether a carefully designed short-term fasting diet might calm these unwanted immune reactions and help you tolerate this medication better.
You would meet with a nutritionist for a one-hour nutrition counseling session to learn about the diet. Then, for three separate cycles of your immunotherapy, you would follow the fasting-mimicking diet for 4 days, and on day 5 gradually transition back to your regular meals using provided guidelines. Throughout the study, you would give blood samples so researchers can check for inflammation markers. After you finish the diet portion, you would have a follow-up visit 6 months later.
AI-generated summary from trial data · Sep 2, 2026 · Not medical advice
United States