Plain-English translation of NCT06442423 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This is an early-stage research study testing , a naturally occurring compound, as a potential treatment for people whose psychiatric symptoms—like depression, anxiety, PTSD, or addiction—are making it hard to function in daily life. The study will give you one oral dose of the medication and then monitor how safe it is and how you respond to it over the following weeks and months. The researchers want to understand whether this treatment could help people with multiple different psychiatric conditions, not just one specific diagnosis.
Most psychiatric research has focused narrowly on single diagnoses with strict eligibility rules, which may not reflect how complex real-world patients actually are. This study exists to test whether this medication is safe and feasible for people with overlapping or multiple psychiatric conditions and significant functional impairment—a more realistic picture of who might benefit from it.
You likely qualify if…
You likely don't qualify if…
You will come to Yale University for a screening visit to confirm you qualify, then return for the dosing session where you will take one 25 mg capsule of the medication by mouth along with supportive counseling before, during, and after. You will have follow-up visits at 1 week, 4 weeks, and 6 weeks after dosing to assess your safety and how you're doing. If you agree, you can also participate in longer-term follow-up assessments at 3 months, 6 months, and 12 months to see if any changes continue or develop over time.
AI-generated summary from trial data · Jun 23, 2026 · Not medical advice
United States