Plain-English translation of NCT06442748 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 3 — Testing in thousands of people, comparing the treatment against what doctors currently use. This is the last big step before approval.
This trial is testing whether patients with brain tumors who have had seizures can safely stop taking (a seizure medication) after their seizures are controlled, or whether it's safer to continue the medication longer. Right now, doctors aren't sure how long patients need to stay on this medication after brain tumor surgery. This study will help answer that question by comparing two groups: one that stops the medication gradually, and one that keeps taking it for two years.
After brain tumor surgery, many patients take seizure medication to prevent seizures, but doctors don't know the best length of time for treatment. Some patients may be able to stop safely earlier, while others might need longer protection. This trial will help doctors make better decisions about when patients can safely come off the medication.
You likely qualify if…
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If you join, you'll be randomly assigned to one of two groups: either continue taking your current dose of the medication for two years, or gradually reduce and stop it over several weeks. You'll visit the clinic every three to six months for checkups, have brain scans every six to twelve months, and complete quality-of-life surveys twice a year. If seizures return in either group, you'll restart the medication and receive additional treatment as needed. The study lasts two years from the time you join.
AI-generated summary from trial data · Jun 13, 2026 · Not medical advice
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