Plain-English translation of NCT06445439 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether adjusting your heart device to pace at a faster speed (80 beats per minute instead of 60) helps you feel better and exercise more easily. You have a special heart device called cardiac resynchronization therapy that helps coordinate your heartbeats, and this study will compare two different pacing speeds over 6 months to see which works best for you.
Recent research suggests that people with certain types of heart failure may actually feel better with a faster heart rhythm, which is different from the traditional approach of slowing the heart down. This trial will help doctors understand what pacing speed gives you the best quality of life and exercise ability.
You will be randomly assigned to one of two groups: one group will start at a pacing speed of 60 beats per minute for 3 months, then switch to 80 beats per minute for the next 3 months, while the other group does the opposite order. Throughout the 6-month study, you'll have your device checked, complete heart tests like an ultrasound and electrocardiogram, do a 6-minute walking test to measure exercise tolerance, and have blood work drawn at the start, 3 months, and 6 months.
AI-generated summary from trial data · Jun 19, 2026 · Not medical advice
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