Plain-English translation of NCT06446245 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether , an antibiotic, can help improve treatment outcomes when added to the standard medications for tuberculosis that affects the brain and nervous system. Researchers believe this medication may reduce death rates and serious nerve damage in patients with this serious form of tuberculosis. The study will track how well the treatment works and whether it is safe to use alongside standard care.
Brain tuberculosis is a severe form of the disease that can cause death or permanent disability even with standard treatment. Researchers want to see if this medication can reduce inflammation in the brain and spinal fluid, potentially preventing long-term nerve damage and improving survival rates.
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If you enroll, you will take twice daily along with your standard tuberculosis medications and corticosteroids for 8 weeks. You will have regular clinic visits to monitor your health, blood tests to check your liver function, and assessments of your neurological condition. After 8 weeks, you will stop the but continue your standard tuberculosis treatment as prescribed by your doctor, with follow-up visits to track your recovery.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
Indonesia
Malaysia
Singapore