Plain-English translation of NCT06446531 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This trial is testing whether medications like Empagliflozin, Rybelsus, or a combination of and Pioglitazone—along with nutritional counseling—can help prevent prediabetes from turning into type 2 diabetes. You would receive the medication or a placebo (inactive pill) for 6 months while attending regular visits with the research team. The goal is to find an affordable and effective way to help Hispanic communities avoid serious health complications.
Prediabetes affects millions of people and often leads to type 2 diabetes and heart disease. This study aims to find which medications work best at stopping that progression, especially in Hispanic communities, and to make treatment affordable and accessible.
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You would visit the research clinic approximately 16 times over 6-7 months. At the start, you'll be randomly assigned to receive either a placebo or one of three different medication regimens, all combined with nutritional counseling from the study team. There are no overnight hospital stays required. The research team will monitor your health through blood tests and other measurements to see how the treatment is working.
AI-generated summary from trial data · Jul 13, 2026 · Not medical advice
United States