Plain-English translation of NCT06451120 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing platelet-rich plasma (PRP)—a treatment made from your own blood—to see if it can help reduce knee arthritis pain and slow joint damage. Researchers will give some participants PRP injections while others receive a saline (salt water) placebo injection, and then track how your body responds over time by measuring changes in blood and joint fluid markers.
Knee arthritis affects millions of people, but current treatments don't always work well and some have side effects. Researchers hope this medication might help by triggering your body's natural healing processes, and they want to understand whether it works differently in younger versus older patients.
You likely qualify if…
You likely don't qualify if…
You'll visit the research clinic three times in person (at baseline, week 2, and week 12), where researchers will draw blood and extract joint fluid, then inject either the PRP treatment or placebo into your knee—a process taking about 45 minutes per visit. You'll also have three remote visits over the following months and complete brief surveys and simple physical function tests at each visit. In total, participation spans about 2 years, with the most intensive phase lasting the first 3 months.
AI-generated summary from trial data · Jun 12, 2026 · Not medical advice
United States