Plain-English translation of NCT06452095 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing hyperbaric oxygen therapy (HBOT) — a treatment where you breathe pure oxygen inside a pressurized chamber — to see if it can help reduce lingering COVID-19 symptoms like brain fog and fatigue. Some participants will receive real high-oxygen treatment, while others will receive a sham (fake) treatment that looks similar but doesn't deliver therapeutic oxygen. Researchers will compare how both groups improve over 8 weeks.
Many people experience long-lasting symptoms months after COVID-19 infection, including difficulty concentrating and extreme tiredness. This trial exists to find out whether increasing oxygen levels in the body through pressurized chambers could help these patients recover when standard treatments haven't fully worked.
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If you join this trial, you will visit one of three locations in Toronto five days a week for 8 consecutive weeks. During each visit, you'll spend 90 minutes in a pressurized chamber breathing either high-concentration oxygen (if in the treatment group) or regular air (if in the control group). The chamber will feel similar regardless of which group you're in. Throughout the study, researchers will assess your symptoms and track how you're feeling to see if the oxygen therapy helps with brain fog, fatigue, and other lingering COVID effects.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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