Plain-English translation of NCT06452160 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Mesothelioma research guide →Phase 1 — Testing in a small group (usually 20–80 people) to find a safe dose and watch for side effects.
This is a Phase I clinical trial testing a new medication called to see if it is safe, well-tolerated, and effective for patients with advanced solid tumors. The trial has two parts: first, researchers will test increasing doses of the medication in smaller groups to find the best dose, and then they will test that dose in larger groups of patients with specific cancer types to see how well it works.
Many patients with advanced cancers like mesothelioma and epithelioid hemangioendothelioma have limited treatment options, especially if standard treatments stop working or cause too many side effects. This medication targets a specific pathway in cancer cells, so researchers want to learn whether this new treatment can help patients whose cancers have progressed despite other therapies.
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You would take a capsule by mouth once daily in 21-day cycles (three weeks on treatment). In the first phase, patients are enrolled at gradually increasing doses to find the safest and most effective dose. Once that dose is determined, the second phase enrolls more patients at that set dose level. Throughout the trial, you would have regular clinic visits for blood tests, imaging scans, and check-ins about how you are tolerating the medication and how your cancer is responding.
AI-generated summary from trial data · Aug 22, 2026 · Not medical advice
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