Plain-English translation of NCT06452849 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Major Depressive Disorder research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a non-invasive brain stimulation technique called temporal interference stimulation to treat depression in teenagers ages 14–18. The treatment uses special magnetic pulses designed to gently stimulate specific areas of the brain involved in mood and emotion. Researchers want to see if this approach can improve depression symptoms and understand how it works.
Many teenagers with depression don't respond well to medication alone, and doctors need new treatment options. This study explores whether targeting specific brain regions with this non-invasive technique could offer a safer, additional way to help teens manage their depression.
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If you join, you will receive brain stimulation sessions for 20 minutes a day over 5 days. The treatment is painless and non-invasive—you'll sit comfortably while the stimulation happens. The study team will monitor your depression symptoms before, during, and after treatment to see how well the technique works for you.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
China
Sponsor
Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Collaborators
Ruijin Hospital
Enrollment target
~60 participants
Started
May 2024
Primary completion
April 2025
This trial's estimated completion date has passed — the record may not be fully up to date.
Age range
14 Years – 18 Years
Last updated on clinicaltrials.gov in June 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
JINGJING HUANG, MD PhD
Shanghai Pudong New Area Mental Health Center, School of Medicine, Tongji University
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.