Plain-English translation of NCT06453317 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Ulcerative Colitis research guide →Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether combining two biologic medications — and — works better than using either one alone for treating moderate to severe ulcerative colitis. The study will compare how well each approach heals the intestine, improves symptoms, and affects quality of life. Researchers also want to understand any side effects from the combination treatment.
Standard treatments for severe ulcerative colitis don't work well enough for all patients, and some people can't tolerate them. This trial explores whether combining two different biologic medications might be more effective than using just one.
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You will be randomly assigned to receive one of three treatments over 52 weeks: alone, alone, or both medications together. The medications are given by infusion or injection on a set schedule (typically starting at weeks 0, 2, and 6, then every 8 weeks). You will visit the clinic regularly for treatment, blood tests, and check-ups to track how well the medication is working, assess your symptoms, and watch for any side effects.
AI-generated summary from trial data · Jun 14, 2026 · Not medical advice
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