Recruiting

Testing a Daily Moisturizer for Atopic Eczema Skin Care

Plain-English translation of NCT06453512 on ClinicalTrials.gov ↗ · Source last updated March 2025 · Translation generated June 2026 · How we translate trials

This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.

What is this trial?

This trial is testing Doublebase Once, a moisturizer cream designed to be used once daily, in people with atopic eczema (a chronic skin condition that causes itching, dryness, and irritation). The study will measure how well the medication reduces eczema symptoms and improves skin moisture levels over four weeks, and will ask participants about their experience using it.

Atopic eczema can be challenging to manage, and this treatment exists to see whether using this medication once a day—instead of multiple times—can effectively control symptoms while being more convenient for patients in everyday life.

Do you qualify?

You likely qualify if…

you have been diagnosed with atopic eczema of any severity
your eczema has a baseline SCORAD score of at least 15 (a measure of eczema severity)
you are currently using a regular moisturizer to manage your eczema
you have not used Doublebase Once or topical/systemic antibiotics in the past month
you are willing to use Doublebase Once once daily as your only leave-on moisturizer for four weeks

You likely don't qualify if…

you are currently taking or have taken systemic or topical antibiotics, or Doublebase Once, in the past month
you have a known allergy or sensitivity to any ingredients in Doublebase Once
you are currently participating in another research study or have done so in the past 30 days
you have difficulty reading and understanding English or completing written questionnaires
you work for the sponsor or investigator, or are an immediate family member of someone who does

What participation looks like

You will visit your GP center at baseline, after one week, and after four weeks. At each visit, a nurse or doctor will assess your skin using a standard scoring system and may take skin hydration measurements. You will use Doublebase Once once daily (or more if needed) as your only leave-on moisturizer for the full four weeks, and you can also use it as a soap substitute. You will keep a daily diary noting how often you use the treatment and any other medicines you need, and you will complete questionnaires about your experience at the start and end of the study.

AI-generated summary from trial data · Jun 9, 2026 · Not medical advice

Trial locations(1 site)

United Kingdom

Cripps Medical Centre, Nottingham, Nottinghamshire