Plain-English translation of NCT06455995 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Obesity research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This study is testing whether eating most of your calories at specific times of day helps people lose weight more effectively. All participants will follow a reduced-calorie diet, increase physical activity, and work with a counselor for 12 months. Some participants will be asked to eat most of their calories in the morning, others in the evening, and a third group will have no specific timing guidance—so researchers can compare which approach works best.
Many people struggle to lose weight and keep it off with standard diet and exercise advice alone. This study is exploring whether timing your meals strategically—such as eating more early in the day versus later—might help regulate your appetite and lead to better, more sustainable weight loss.
You likely qualify if…
You likely don't qualify if…
You will join one of three groups for 12 months. All groups will follow a reduced-calorie, low-fat meal plan, aim for over 200 minutes of moderate physical activity per week, and attend counseling sessions focused on healthy behavior change. Depending on your group assignment, you may be asked to eat most of your calories in the morning, in the evening, or with no specific timing guidance. You'll have study visits at 0, 3, 6, and 12 months where researchers will measure your weight, review your eating patterns (using food photos and glucose monitors), track your sleep and appetite using a smartphone app, and assess other health markers.
AI-generated summary from trial data · Jun 22, 2026 · Not medical advice
United States