Plain-English translation of NCT06456983 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Schizophrenia research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a combination of two treatments works better than medication alone for people with schizophrenia that hasn't responded to clozapine. The trial combines clozapine with maintenance electroconvulsive therapy (ECT), a procedure where controlled electrical currents help reset brain activity. Researchers believe this combination might help people stay well longer and improve their quality of life.
Some people with schizophrenia don't get better even with clozapine, the strongest antipsychotic medication available. This trial exists to find out whether adding this brain stimulation treatment to the medication might help people who haven't improved with medication alone.
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The trial has two main phases. First, you would receive a series of up to 18 ECT treatments over 6–9 weeks while continuing your regular antipsychotic medication to see if this helps you improve. If you improve by at least 30%, you would then be randomly assigned to either continue with medication alone or receive medication plus ongoing maintenance ECT treatments over 28 weeks. The entire study lasts about 1 year per participant, with regular visits to monitor your symptoms, functioning, and well-being.
AI-generated summary from trial data · Jun 2, 2026 · Not medical advice
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