Plain-English translation of NCT06457451 on ClinicalTrials.gov ↗ ·
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether a combination of personalized nutrition support and adapted physical activity can help adults with cystic fibrosis who are taking Elexacaftor-Tezacaftor-Ivacaftor build and maintain lean muscle mass. The newer cystic fibrosis medication has helped many patients gain weight and improve lung function, but researchers want to make sure that weight gain includes healthy muscle, not just fat. This study looks at whether a coordinated program with a dietitian and exercise specialist can help patients achieve the best possible muscle health over one year.
The newer cystic fibrosis medication has been transformative for patients, but it's also created new nutritional challenges—some patients are now gaining unhealthy weight or developing metabolic problems. Researchers want to understand whether structured support in diet and exercise can help patients build muscle and avoid these complications while benefiting from the medication.
You likely qualify if…
You likely don't qualify if…
If you join this trial, you'll be assigned to either the structured program or usual care. If you're in the program group, you'll work with a dietitian and exercise specialist for one year. You'll start with two supervised online exercise sessions per week plus in-person nutrition visits every three months, then gradually shift to more independent exercise with phone check-ins. Throughout, your dietitian will help you set personalized nutrition goals and monitor your progress. The whole commitment is one year, with regular contact to support you.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
France