Plain-English translation of NCT06460805 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing a special nutrition diet called Partial Enteral Nutrition (PEN) — which combines a medical liquid formula with regular whole foods — in people with axial spondyloarthritis, a condition that causes inflammation in the spine and joints. Researchers believe this diet may help calm inflammation in the gut and reduce overall inflammation in the body, similar to how it helps some people with inflammatory bowel disease. The study will compare how the diet affects people with this condition versus healthy volunteers.
People with axial spondyloarthritis often have inflammation and an imbalanced community of bacteria in their gut, similar to what happens in inflammatory bowel disease. This medication has been proven to help people with inflammatory bowel disease, but no one has tested whether it might also help people with axial spondyloarthritis by improving gut health and reducing inflammation throughout the body.
If you join, you'll follow the Partial Enteral Nutrition diet for two weeks (with an option to continue for another two weeks if you wish). The diet consists of a medical liquid formula combined with regular whole foods. During this time, researchers will collect blood samples and stool samples to measure inflammation markers and changes in your gut bacteria, and they'll track how your symptoms respond to the diet.
AI-generated summary from trial data · Jun 5, 2026 · Not medical advice
United Kingdom