Plain-English translation of NCT06462378 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing proton therapy—a specialized type of radiation treatment—combined with chemotherapy and internal radiation (brachytherapy) for patients with advanced cervical cancer. Proton therapy works by targeting cancer cells with charged particles that may damage healthy tissue less than standard radiation. The goal is to keep cancer control high while reducing both short-term and long-term side effects from treatment.
Standard radiation therapy for advanced cervical cancer can cause significant side effects to nearby organs. Researchers believe proton therapy may deliver radiation more precisely to the cancer, sparing healthy tissue and reducing complications, while maintaining the same cancer-fighting effectiveness.
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You would receive proton therapy delivered over several weeks, along with chemotherapy (platinum-based drugs given during treatment) and internal radiation therapy (brachytherapy) performed by your doctor. You'll have imaging scans to plan and adjust your treatment, and regular follow-up visits to monitor how well the treatment is working and to check for any side effects. The full course of treatment typically lasts several weeks, with ongoing follow-up afterward.
AI-generated summary from trial data · Jun 16, 2026 · Not medical advice
Denmark
Phase
Testing effectiveness
Sponsor
University of Aarhus
Collaborators
Aarhus University Hospital
Enrollment target
~55 participants
Started
May 2024
Primary completion
May 2029
Age range
18 Years – 99 Years
Sex
Female only
Last updated on clinicaltrials.gov in June 2024.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Hanne Matthiesen, MD, PhD
Department of Oncology, Capital Region Denmark
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.