Plain-English translation of NCT06464458 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Read our Sickle Cell Disease research guide →This study doesn't follow the usual testing phases — it may be an observational study or a different type of research.
This trial is testing whether using specific blood test measurements to adjust hydroxyurea doses helps doctors better manage sickle cell disease in young patients. Hydroxyurea is a medication already used to treat sickle cell disease, but doctors aren't always sure what the best dose is for each person. This study will compare two approaches to dosing the medication: one based on traditional blood counts, and one using additional laboratory measurements to personalize the dose even more.
Sickle cell disease causes painful crises and serious health problems, and while this medication can help reduce these episodes, finding the right dose for each patient is challenging. This trial wants to see if measuring how much of the medication is actually in your body can help doctors adjust your dose more precisely and improve your care.
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You will have an initial information visit where the study is explained, followed by a formal consent visit. Then you will be randomly assigned to one of two groups that differ in how your medication dose is adjusted based on blood test results. Over the course of the study, you'll have multiple visits where blood samples are drawn to measure your blood counts and medication levels, and your dose will be adjusted based on these results. The study team will work with you to find the dose that works best while managing any side effects.
AI-generated summary from trial data · Jun 3, 2026 · Not medical advice
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