Plain-English translation of NCT06466434 on ClinicalTrials.gov ↗ · Source last updated · Translation generated · How we translate trials
Phase 2 — Testing in a bigger group (up to a few hundred people) to see if the treatment actually works and is still safe.
This trial is testing whether a special diet rich in prebiotic foods—foods that feed the healthy bacteria in your gut—can help improve how well your body responds to immunotherapy for melanoma. Immunotherapy works by boosting your immune system to fight cancer, and researchers believe that having a healthier gut microbiome (the community of bacteria in your digestive system) may make this treatment even more effective. You would receive the prebiotic foods along with your standard cancer medication.
Recent research suggests that the bacteria living in your gut play an important role in how well immunotherapy works. This trial exists to see whether eating foods that support healthy gut bacteria can improve treatment outcomes and help more patients benefit from their melanoma therapy.
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Over 24 weeks, you would receive specially prepared prebiotic food snacks and nutritional counseling to help you eat more prebiotic-rich foods while you receive your immunotherapy treatment. You would visit MD Anderson for regular check-ups, blood draws, and stool sample collection at baseline, 12 weeks, and 24 weeks. The study team will monitor how well the treatment works, how you tolerate the diet, any side effects, and how the diet affects your gut bacteria and your overall health.
AI-generated summary from trial data · Jun 7, 2026 · Not medical advice
United States
Phase
Testing effectiveness
Sponsor
M.D. Anderson Cancer Center
Enrollment target
~75 participants
Started
September 2024
Primary completion
June 2027
Age range
18 Years and older
Last updated on clinicaltrials.gov in March 2026.
Reach out to the team running this trial. Response times vary — some teams are faster than others.
Central contact
Erez Baruch, MD,PHD
M.D. Anderson Cancer Center
Tell us you're interested and we'll help connect you with the research team. We'll walk you through what to expect first — no email needed to get started.