Try combined brain training exercises to improve memory and thinking skills

Back to HIV-associated Neurocognitive Disorders trials

Recruiting

What is this trial?

This research study is testing whether a combination of two brain training programs — CogSMART and BrainHQ — can help people living with HIV who are experiencing memory, concentration, or thinking problems. CogSMART teaches practical strategies to work around cognitive challenges, while BrainHQ uses game-like exercises to strengthen memory and attention. Together, these programs aim to help you improve daily tasks and quality of life.

Many people living with HIV experience cognitive problems even when their virus is well-controlled by medication, but there are currently no established treatments to address this issue. This trial exists to see whether combining practical strategies with brain exercises can help reduce these cognitive difficulties and improve people's ability to manage their health, work, and daily responsibilities.

Do you qualify?

You likely qualify if…

you are between 30 and 50 years old
you have been diagnosed with HIV and are currently taking antiretroviral therapy
you speak Xhosa fluently
you have completed at least 8 years of schooling
you have been diagnosed with HIV-related cognitive difficulties (mild to moderate memory, attention, or thinking problems)
you are willing to attend brain training sessions twice a week for five weeks

You likely don't qualify if…

you have a serious mental health condition such as schizophrenia or bipolar disorder
you have a neurological condition like epilepsy or multiple sclerosis
you are currently undergoing chemotherapy or radiation treatment
you are legally blind or deaf
you have a history of severe head injury with loss of consciousness lasting longer than 30 minutes

What participation looks like

If you join this study, you will attend sessions over five weeks in South Africa. You'll complete two cognitive testing appointments with a specialist, participate in ten CogSMART strategy sessions, and complete ten brain training sessions using the BrainHQ computer program. Sessions are 30 minutes long, and in total you'll commit about 10 hours to the program. Some participants will receive additional support materials during the study.

Brain training programs for HIV-related memory and thinking problems

What is this trial?

Do you qualify?

What participation looks like

Trial locations(3 sites)