Testing Two Doses of a Common Blood Thinner During Pregnancy

Plain-English translation of NCT06468202 on ClinicalTrials.gov ↗ · Source last updated May 2026 · Translation generated July 2026 · How we translate trials

Phase 4 — The treatment has already been approved. Researchers are tracking how it works in a large number of people over time.

What is this trial?

This trial is testing whether aspirin — a common, inexpensive medication — can prevent serious high blood pressure problems during pregnancy. Researchers want to find out if a higher daily dose (162 mg) works better than a lower dose (81 mg) at preventing these dangerous complications, which affect about 1 in 7 pregnant people.

High blood pressure during pregnancy can seriously harm both mother and baby, but there are currently no reliable treatments once it develops. This medication shows promise for prevention, but doctors don't know which dose works best or whether it works equally well for all groups of pregnant people.

Do you qualify?

You likely qualify if…

you are at least 14 years old and pregnant (or plan to become pregnant very soon)
you are early in pregnancy — no more than 16 weeks and 6 days along
you have at least one high-risk factor, such as a prior pregnancy with preeclampsia, current high blood pressure, diabetes, twin pregnancy, kidney disease, or an autoimmune condition
or you have at least two moderate-risk factors, such as being 35 or older, having obesity, being a first-time mother, or having a family history of preeclampsia
you are not already taking aspirin for a heart or stroke-related reason

You likely don't qualify if…

you are allergic to aspirin or cannot safely take it due to conditions like stomach ulcers, asthma triggered by NSAIDs, or bleeding disorders
you are taking aspirin for reasons other than pregnancy (such as heart disease prevention) before pregnancy
you are carrying triplets or higher-order multiples, or have a monoamniotic twin pregnancy (twins sharing a fluid sac)
you have a known fetal abnormality, genetic problem, fetal death, or are planning to end the pregnancy
you are under 14 years old or unable to make your own medical decisions

What participation looks like

You will be randomly assigned to take either the lower dose or the higher dose of the medication as one or two daily pills from early pregnancy until delivery. You'll have regular pregnancy visits with your care team, who will monitor your blood pressure and health throughout your pregnancy and track any side effects or complications. The study will follow you and your baby after birth to measure how well the medication worked.

AI-generated summary from trial data · Jul 1, 2026 · Not medical advice

Trial locations(16 sites)

United States

University of Alabama at Birmingham, Birmingham, Alabama

Cedars Sinai Medical Center, Los Angeles, California

University of California, San Francisco, San Francisco, California

Northwestern University, Chicago, Illinois

University of Mississippi, Jackson, Mississippi